I go into some peoples offices and they have their screen resolution set so tiny that you can barely read it. I sometimes comment on it, and they say its because they have to see multiple windows at once etc., etc. I always set mine to the biggest practical font size and haven't had problems with my eyes at all.

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1985 380SE Blue/Blue - 230,000 miles
2012 Subaru Forester 5-speed
2005 Toyota Sienna
2004 Chrysler Sebring convertible
1999 Toyota Tacoma