I used it in the transmission on my 2001 Dodge 1500. It was having a typical problem for that transmission. It pulsed in and out of overdrive on hills. Junk builds up on the screen for the OD solenoids. Seafoam greatly improved it within 50 miles. After 500 miles I no longer have the issue at all.

I've used it to fill my spin on filter when changing. You get huge clouds of black smoke when you do that and take it on 0-60 runs. More that just an Italian Tuneup would give you.

-Jim

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1995 S350D, Green with black leather interior.
Bought January 2008 w/ 233,xxx miles.
I did 22,000 miles during the first year of ownership.