Definitely go to Burbank. John Wayne is way too far to drive to get to Thousand Oaks. Just take the 101 from BUR. The rental for Hertz is on site at the end of the terminal. Budget is off site (about 2 blocks from the airport). Enterprise is across the street.
If you run mapquest directions anywhere, double the time to be safe if you have appointments. Unless you're driving after 8PM.
Sometimes you run into Jay Leno putting about in one of his cars around the airport.
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