Its strange that you should ask if there are any known problems with the W210.
My battery went dead today on my 98 E320. I believe that the batterys life spent its 9 lives. The car was purchased in Sept. of 1997. Fortunately the battery died in my garage (didn't need a tow).
Other than my sunroof problems and a few burned out light bulbs, this car has been very reliable.
With snow tires on in the Chicago winters, the car handles very well. Without snow tires on in the Chicago winters, the car handles very poorly.
I would recommend synthetic oil and change it more often than the FSS recommends.
1998 Mercedes E320, 200K Miles
2001 Acura 3.2TL, 178K Miles
1992 Chevy Astro, 205K Miles