I would say no. However, you should probably keep a little closer eye on the coolant level. When mine is plugged in I hear some noise (like boiling water) and some pressure builds up overnight. So some coolant evaporation may be occurring....probably more than if it were just sitting there.

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1976 240D
1987 560SL
2007 E320 Bluetec
1998 C280 (now son’s car)
1982 240D Manual - Sold