It will be a simple install on the F350 - as you can most likely use the dual mount filtration set up from amsoil - the adapter should fit and there should be plenty of room to stash the unit. On the MB, the space can be a problem, as well as finding the proper adapters etc. I dont think either way will be a big deal technically. If you plan on keeping the car another 100k maybe you should go for it.

__________________
2004 Ram 2500 Cummins HO
2000 Jetta TDI
1999 E300 (sold)