First of all... I would run a bottle or TWO of TECHRON (bought @ Chevron) through your gas tank, preferably, but not needed, before an oil change.
Secondly, MBUSA Recommends fuel filter replacement at 60k miles on gasoline engines, although it doesn't require replacement... Mine was replaced at 80k for the first time and it was definitly time!
2006 E350 w/ 155k miles (Daily Driver)
1993 300E 3.2L Sedan w/ close to about 300k miles
2003 E500 Brilliant Silver (Had 217k miles when totalled!)
1989 300E with 289,000 miles (had for <1 yr while in HI)
03 CLK 500 cabrio (Mom's)
2006 C230k (Dad's)
1999 S420 (Mom's/Dad's)
2000 C230k Sport sedans
2001 CLK320 Cabrio (Mom's)
1995 C280 My First Mercedes-Benz... (155k miles. EXCEPTIONAL AUTOMOBILE. Was Very hard to let go of!)