See the sticky thread near the top of the Tech Help page, "W220/C215 instrument cluster recall". The recall addresses an issue that also plagues the W208 cluster, but that model is not included in the campaign.

Beyond that and your aforementioned top issues, mine has been stellar.

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2009 ML350 (106K) - Family vehicle
2001 CLK430 Cabriolet (80K) - Wife's car
2005 BMW 645CI (138K) - My daily driver
2016 Mustang (32K) - Daughter's car