No question that 2000 S-Class is a leader in luxury sedan market. Hi-tech, safe and great performance(S500). I think the only let down of the car is the plastic parts used in the interior, and the visible springs for trunk. So, don't expect the "richness" of leather/wood/suede in W140 S-Class to be found in W220 S-Class. Hopfully MB will address that problem when the new CL-Class comes out.
P.S. It's really sad to see that even E320 has better quality parts(if not better, at least looks richer) in the interior than W220 S-Class........