Yes, clockwise for harder shifts, counterclockwise for softer.
The red one fits a number of cars from 190E2.6 to 560SEL. It may have a different profile for movement versus vacuum but I doubt it would be so severe that a little adjustment couldn't make if work. You are right that your car should have the "Natural" one.
Bosch Master, ASE Master, L1
33 years MB technician