I haven't driven my car w/o a cluster but I have started it and let it run w/o one and other than obviously not having any gauges, nothing was wrong. I'd say go for it.
Then if a cop asks you the famous question, "Do you know how fast you were going?" you can truthfully say "No, officer!":p
'86 420SE Euro
904 Midnight Blue, Gray Velour
Dad bought it new, now I own it.
"A Mercedes-Benz is like a fine wine, it only gets better with age."