Yes, you can take both pads out at the same time for the single piston caliper front caliper.
But if you change the rear brake pads, the rear caliper is a 2 piston fixed caliper, and then only do one pad at a time.
1999 Dodge Ram 2500 Cummins Diesel
2002 Harley-Davidson Fatboy
Merlin Extralight w/ Campy Record