You betcha. The wide open oil loss from a missing oiler-tube end plug drops the engine oil pressure to 1 bar or less when hot.
This causes adverse effects on the cam timers which are opereated by oil pressure. The knock sensors also pick up the racket and start to goof with timing.
I recommend people do not drive their cars in this condition for extended periods, because I have seen damage to the cams and lifter tappets result.