I doubt if the lines for the vacuum pump trigger signals at the door/trunk locks could be the source of the fuse blowing, but the pump itself likely is. It is located under the rear seat bottom, encased in foam. Unplug it and see if the fuse-blowing stops. If so, the pump itself is the culprit.
Note that if you have an air leak to one of the lock actuators, the pump will keep on running until it overheats and blows a fuse.
'91 MB 190E 2.3
'08 RAV4 Ltd 3.5
'83 Lazy Daze m'home 5.7