jeremy,

My daughter drove our 1982 240D stick with 296,000 miles from Connecticut to San Diego via Durango and Las Vegas, stopping at nearly every National Park on the way. Then she drove it home, through Texas to see her uncle, and up through the Blue Ridge Mtns. It arrived home with 306,000 miles and is headed to 310,000 shortly. It got a little hot in the desert when the outside air temperature in August reached nearly 120*F. Make sure the car is as good a condition as you can manage before leaving, bring a set of fan belts, some tools, and the other stuff mentioned above, as well as a couple gallons of MB antifreeze mixed with water. Good luck, and keep us posted, Jim

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Own:
1986 Euro 190E 2.3-16 (291,000 miles),
1998 E300D TurboDiesel, 231,000 miles -purchased with 45,000,
1988 300E 5-speed 252,000 miles,
1983 240D 4-speed, purchased w/136,000, now with 222,000 miles.
2009 ML320CDI Bluetec, 89,000 miles

Owned:
1971 220D (250,000 miles plus, sold to father-in-law),
1975 240D (245,000 miles - died of body rot),
1991 350SD (176,560 miles, weakest Benz I have owned),
1999 C230 Sport (45,400 miles),
1982 240D (321,000 miles, put to sleep)