As long as it's well taken care of, I don't see any problems with high mileage at all. But truth is that with such high mileage in shorter than average time period, the previous owner may have skipped/ignored some of the major maintianence.
My suggestion is, do a research on the history of the car, find out which dealer/service adivsor serviced the car, and go have a chat with them face in face. Also, find out what has been done on the car in terms of repairs and services. Have the dealer print you a copy of the service history is highly advised.
1992 Mercedes-Benz 400SE
2002 Acura TL Type S