I guess if you feel like experimenting, a Honda is a good test mule. I wouldn't, however, recommend long-term use of acetone additive. While it could aid combustion, all the sensors, seals, etc. in the fuel system could easily be harmed. Most everything I have read says ethanol accomplishes much the same task and would be much more mild on the fuel system.

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Keep everything as simple as possible-but no simpler--Albert Einstein