I wouldn't think so, but you never know.
I'd make sure to have a good tool set of ratchets, and probably some screw drivers.
I have removed radiators on every car of mine except the benz, and all came out relatively easy.
Remove all bolts that hold it to the car, remove hoses, and pull the sucker out.
Now it may or may not be that easy, but on the cars I had done it on, it was that easy..
'92 300CE - Sold
2004 C240 - C7 Wheels
2015 ML350 - P1, Pano, Ash poplar wood, Sport Dinamica interior, Running Boards Keyless go.