I see that the standard method for replacing the W210 cabin filters is by removing the glove box. However, I've noticed that, on some other models where that's the standard method, some find it simpler to go through the engine compartment.

Quick way to change cabin Air Filter - Mercedes-Benz Forum

Cabin Filters Replaced via Engine Bay Access! - Mercedes-Benz Forum

Would this method work with my W210?

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14 E250 Bluetec "Sinclair", Palladium Silver on Black, 153k miles
06 E320 CDI "Rutherford", Black on Tan, 171k mi, Stage 1 tune, tuned TCU
91 300D "Otis", Smoke Silver, 142k mi, wastegate conversion

19 Honda CR-V EX 61k mi
Fourteen other MB's owned and sold
1961 Very Tolerant Wife

Your links are not for W210's.

Charcoal activated filters are behind the glove box, I think the cabin filter is up under the pass side foot well cover.

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Terry Allison
N. Calif. & Boca Chica, Panama

09' E320 Bluetec 77k (USA)
09' Hyundai Santa Fe Diesel 48k (S.A.)

Yes, I knew that....just wondering if same approach would work.

I believe it's the cabin filters that are behind glove box. PeachPartsWiki: Cabin Filter Replacement

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14 E250 Bluetec "Sinclair", Palladium Silver on Black, 153k miles
06 E320 CDI "Rutherford", Black on Tan, 171k mi, Stage 1 tune, tuned TCU
91 300D "Otis", Smoke Silver, 142k mi, wastegate conversion

19 Honda CR-V EX 61k mi
Fourteen other MB's owned and sold
1961 Very Tolerant Wife

Correct, I had it reversed. Havent had mine for a year or two now.

PeachPartsWiki: Cabin Filter Replacement

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Terry Allison
N. Calif. & Boca Chica, Panama

09' E320 Bluetec 77k (USA)
09' Hyundai Santa Fe Diesel 48k (S.A.)

On the 210 you can only access the cabin filter through the glove box.
https://www.youtube.com/watch?v=gDboacPaU8M

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CENSORED due to not family friendly words

Go through inside cabin by removing the glove box by removing it - be certain ALL screws are removed from the glove box surround before pulling on it. You'll think the mofo has a mind of it's own by how it doesn't want to give up staying in place as you pull on the glove box.

That's good to know....I'm always afraid I'm going to break something that won't budge....I wonder what causes the resistance.

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14 E250 Bluetec "Sinclair", Palladium Silver on Black, 153k miles
06 E320 CDI "Rutherford", Black on Tan, 171k mi, Stage 1 tune, tuned TCU
91 300D "Otis", Smoke Silver, 142k mi, wastegate conversion

19 Honda CR-V EX 61k mi
Fourteen other MB's owned and sold
1961 Very Tolerant Wife

Precision German engineering.

But they're jacking with the wrong German, here......

On my '99 E320 (gas) there was an electronics box on the right side. If you opened it up, pulled out four or five boards and then removed the box itself, you'd just about be able to touch the cabin air filter. When the mouse took up residence, it was very happy moving between the air filter enclosure and the computer enclosure. Sort of a $50,000 Habitat.

I ramble...the answer is, no, you can't.