There's a thread over on Benzworld seeing what kind of miles people are getting with their 05/06 E320 CDI's. The suggestion has been made that that the OM647 may serve as something of a proxy for how far the OM648 may last. The OM647 is in Sprinters....same engine, one less cylinder. More of them out there that have racked up high miles. Looks like 500-600k is achievable. I'm good with that!

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14 E250 Bluetec "Sinclair", Palladium Silver on Black, 153k miles
06 E320 CDI "Rutherford", Black on Tan, 171k mi, Stage 1 tune, tuned TCU
91 300D "Otis", Smoke Silver, 142k mi, wastegate conversion

19 Honda CR-V EX 61k mi
Fourteen other MB's owned and sold
1961 Very Tolerant Wife

Can’t help a lot as I have just passed 100,000 miles.

I would think that a I-6 would be a smoother engine than the I-5 and should last longer.

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1999 Mercedes E300TD daily driver sold at 238K miles 106K miles were mine, rust worm got it :-(
2006 Mercedes CDI new daily driver! 56,000 miles May 2016 now 85,625 Apr 2018 and Apr 2019 101,000 miles Apr 2020 109,875. March 2024 135,250