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  #1  
Old 11-28-2004, 10:56 PM
MedMech
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Paralyzed woman walks again after stem cell therapy

Keep in mind they used umbilical cord blood not a dead (murdered) baby.


Paralyzed woman walks again after stem cell therapy


AFP Photo

A South Korean woman paralyzed for 20 years is walking again after scientists say they repaired her damaged spine using stem cells derived from umbilical cord blood.

Hwang Mi-Soon, 37, had been bedridden since damaging her back in an accident two decades ago.

Last week her eyes glistened with tears as she walked again with the help of a walking frame at a press conference where South Korea researchers went public for the first time with the results of their stem-cell therapy.

They said it was the world's first published case in which a patient with spinal cord injuries had been successfully treated with stem cells from umbilical cord blood.

Though they cautioned that more research was needed and verification from international experts was required, the South Korean researchers said Hwang's case could signal a leap forward in the treatment of spinal cord injuries.

The use of stem cells from cord blood could also point to a way to side-step the ethical dispute over the controversial use of embryos in embryonic stem-cell research.

"We have glimpsed at a silver lining over the horizon," said Song Chang-Hoon, a member of the research team and a professor at Chosun University's medical school in the southwestern city of Kwangju.

"We were all surprised at the fast improvements in the patient."

Under TV lights and flashing cameras, Hwang stood up from her wheelchair and shuffled forward and back a few paces with the help of the frame at the press conference here on Thursday.

"This is already a miracle for me," she said. "I never dreamed of getting to my feet again."

Medical research has shown stem cells can develop into replacement cells for damaged organs or body parts. Unlocking that potential could see cures for diseases that are at present incurable, or even see the body generate new organs to replace damaged or failing ones.

So-called "multipotent" stem cells -- those found in cord blood -- are capable of forming a limited number of specialised cell types, unlike the more versatile "undifferentiated" cells that are derived from embroyos.

However, these stem cells isolated from umbilical cord blood have emerged as an ethical and safe alternative to embryonic stem cells.

Clinical trials with embryonic stem cells are believed to be years away because of the risks and ethical problems involved in the production of embryos -- regarded as living humans by some people -- for scientific use.

In contrast, there is no ethical dimension when stem cells from umbilical cord blood are obtained, according to researchers.

Additionally, umbilical cord blood stem cells trigger little immune response in the recipient as embryonic stem cells have a tendency to form tumors when injected into animals or human beings.

For the therapy, multipotent stem cells were isolated from umbilical cord blood, which had been frozen immediately after the birth of a baby and cultured for a period of time.

Then these cells were directly injected to the damaged part of the spinal cord.

"Technical difficulties exist in isolating stem cells from frozen umbilical cord blood, finding cells with genes matching those of the recipient and selecting the right place of the body to deliver the cells," said Han Hoon, president of Histostem, a government-backed umbilical cord blood bank in Seoul.

Han teamed up with Song and other experts for the experiment.

They say that more experiments are required to verify the outcome of the landmark therapy.

"It is just one case and we need more experiments, more data," said Oh Il-Hoon, another researcher.

"I believe experts in other countries have been conducting similar experiments and accumulating data before making the results public."

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  #2  
Old 11-29-2004, 10:06 AM
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I tend to be sceptical of "Mirical cures" and this one fits that to a "T".

It there was any truth to it it would be headline news on every radio,TV and Newspapers. I have yet to see anything.
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Old 11-18-2008, 10:57 PM
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Doctors transplant windpipe with stem cells

By MARIA CHENG, AP Medical Writer
1 hr 53 mins ago
LONDON – Doctors have given a woman a new windpipe with tissue grown from her own stem cells, eliminating the need for anti-rejection drugs. "This technique has great promise," said Dr. Eric Genden, who did a similar transplant in 2005 at Mount Sinai Hospital in New York. That operation used both donor and recipient tissue. Only a handful of windpipe, or trachea, transplants have ever been done.
If successful, the procedure could become a new standard of treatment, said Genden, who was not involved in the research.
The results were published online Wednesday in the medical journal, The Lancet.
The transplant was given to Claudia Castillo, a 30-year-old Colombian mother of two living in Barcelona, suffered from tuberculosis for years. After a severe collapse of her left lung in March, Castillo needed regular hospital visits to clear her airways and was unable to take care of her children.
Doctors initially thought the only solution was to remove the entire left lung. But Dr. Paolo Macchiarini, head of thoracic surgery at Barcelona's Hospital Clinic, proposed a windpipe transplant instead.
Once doctors had a donor windpipe, scientists at Italy's University of Padua stripped off all its cells, leaving only a tube of connective tissue.
Meanwhile, doctors at the University of Bristol took a sample of Castillo's bone marrow from her hip. They used the bone marrow's stem cells to create millions of cartilage and tissue cells to cover and line the windpipe.
Experts at the University of Milan then used a device to put the new cartilage and tissue onto the windpipe. The new windpipe was transplanted into Castillo in June.
"They have created a functional, biological structure that can't be rejected," said Dr. Allan Kirk of the American Society of Transplantation. "It's an important advance, but constructing an entire organ is still a long way off."
So far, Castillo has shown no signs of rejection and is not taking any immune-suppressing drugs, which can cause side effects like high blood pressure, kidney failure and cancer.
"I was scared at the beginning," Castillo said in a press statement. "I am now enjoying life and am very happy that my illness has been cured."
Her doctors say she is now able to take care of her children, and can walk reasonable distances without becoming out of breath. Castillo even reported dancing all night at a club in Barcelona recently.
Genden said that Castillo's progress needed to be closely monitored. "Time will tell if this lasts," he said. Genden added that it can take up to three years to know if the windpipe's cartilage structure is solid and won't fall apart.
People who might benefit include children born with defective airways, people with scars or tumours in their windpipes, and those with collapsed windpipes.
Martin Birchall, who grew Castillo's cells at the University of Bristol, said that the technique might even be adapted to other organs.
"Patients engineering their own tissues is the key way forward," said Dr. Patrick Warnke, a surgeon at the University of Kiel in Germany. Warnke is also growing patients' tissues from stem cells for transplants.
Warnke predicted that doctors might one day be able to produce organs in the laboratory from patients' own stem cells. "That is still years away, but we need pioneering approaches like this to solve the problem," he said.
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Old 11-19-2008, 01:05 AM
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Banking on cord blood

To save or not to save? That is the latest question expectant parents are being pounded with these days, as they decide whether to bank their newborn's umbilical cord blood for possible medical use later in life.

"It's like insurance," says Dr. Lawrence Horn, a gynecologist in Huntington. "I've been recommending it for a few years." Not just for the baby but for the potential health benefit of siblings, parents, even complete strangers.

Cord blood is rich in stem cells, which are the building blocks of the immune system and all other blood cells. Saving it, says Horn, virtually guarantees you'll have genetically matched stem cells on hand in the tiny chance that the child or someone else in the family suffers from a treatable blood disorder or needs a bone marrow transplant. Even people unrelated to the donor could be a genetic match.

So far, cord blood stem cells (not to be confused with controversial embryonic stem cells) have been used in about 6,000 transplants to treat leukemia, lymphoma, blood disorders and some genetic diseases. Scientists say they believe cord blood might soon be used to repair heart or nerve tissue damaged by strokes, Alzheimer's and Parkinson's diseases or spinal cord injuries.

In the meantime, Congress is considering legislation that would create a federally funded national registry of donated cord blood, which has successfully been used in stem cell transplants between unrelated people.

Remainder of article:
http://www.newsday.com/news/health/ny-adcova4452831oct03,0,3700976.story?coll=ny-health-headlines
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Old 11-19-2008, 06:58 AM
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This is the same as the "cancer cure" of last week. Its a 1:1,000,000,000 chance event and it will probably never be repeated since it was likely a fraud.

Her back probably had minor damage and she was avoiding the hospital. Fix the problem, throw a little cord blood in there and BAM, its miracle of science.

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