On my E320 I am getting 4 different codes they are

P0173 Fuel Trim Malfuction Bank 2
P0170 Fuel Trim Malfuntion Bank 1
P0300 Multiple Cylinder Misfire Detected
P0300 Cylinder 1 Misfire detected.

I replaced the spark plugs. Also I replaced the Cylinder 1 ignition coil with cylinder 2, also replaced the ignition wires with cylinder 3 to find the problem on the misfire. however it still displays misfire on cylinder 1. Any ideas?

What about Fuel trim malfunction, what should I check for those errors?

The most likely cause of ALL of your problems is the mass air flow sensor....

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