Mistake Leading to Discovery: Recreational drug use
Lesson Learned: Too much of a good thing can sometimes be, well, a good thingNitrous oxide was discovered in 1772, but for decades the gas was considered no more than a party toy. People knew that inhaling a little of it would make you laugh (hence the name “laughing gas”), and that inhaling a little more of it would knock you unconscious. But for some reason, it hadn’t occurred to anyone that such a property might be useful in, say, surgical operations.
Finally, in 1844, a dentist in Hartford, Conn., named Horace Wells came upon the idea after witnessing a nitrous mishap at a party. High on the gas, a friend of Wells fell and suffered a deep gash in his leg, but he didn’t feel a thing. In fact, he didn’t know he’d been seriously injured until someone pointed out the blood pooling at his feet.
To test his theory, Wells arranged an experiment with himself as the guinea pig. He knocked himself out by inhaling a large does of nitrous oxide, and then had a dentist extract a rotten tooth from his mouth. When Wells came to, his tooth had been pulled painlessly. To share his discovery with the scientific world, he arranged to perform a similar demonstration with a willing patient in the amphitheatre of the Massachusetts General Hospital. But things didn’t exactly go as planned. Not yet knowing enough about the time it took for the gas to kick in, Wells pulled out the man’s tooth a little prematurely, and the patient screamed in pain. Wells was disgraced and soon left the profession. Later, after being jailed while high on chloroform, he committed suicide. It wasn’t until 1864 that the American Dental Association formally recognized him for his discovery.