By SETH BORENSTEIN, AP Science Writer Wed Dec 20, 5:54 PM ET
WASHINGTON - Maybe it's germs that are making you fat.

Researchers found a strong connection between obesity and the levels of certain types of bacteria in the gut. That could mean that someday there will be novel new ways of treating obesity that go beyond the standard advice of diet and exercise.

According to two studies being published in Thursday's issue of the journal Nature, both obese mice and people had more of one type of bacteria and less of another kind.

A "microbial component" appears to contribute to obesity, said study lead author Jeffrey Gordon, director of Washington University's Center for Genome Sciences.

Obese humans and mice had a lower percentage of a family of bacteria called Bacteroidetes and more of a type of bacteria called Firmicutes, Gordon and his colleagues found.

The researchers aren't sure if more Firmicutes makes you fat or if people who are obese grow more of that type of bacteria.

But growing evidence of this link gives scientists a potentially new and still distant way of fighting obesity: Change the bacteria in the intestines and stomach. It also may lead to a way of fighting malnutrition in the developing world.

"We are getting more and more evidence to show that obesity isn't what we thought it used to be," said Nikhil Dhurandhar, a professor of infection and obesity at Louisiana State University's Pennington Biomedical Research Center.

"It isn't just (that) you're eating too much and you're lazy."

Dhurandhar wasn't part of the research, but said it may change the way obesity is treated eventually.

He said the field of "infectobesity" looks at obesity with multiple causes, including viruses and microbes. In another decade or so, the different causes of obesity could have different treatments. The current regimen of diet and exercise "is like treating all fevers with one aspirin," Dhurandhar said.

In one of the two studies in Nature, Gordon and colleagues looked at what happened in mice with changes in bacteria level. When lean mice with no germs in their guts had larger ratios of Firmicutes transplanted, they got "twice as fat" and took in more calories from the same amount of food than mice with the more normal bacteria ratio, said Washington University microbiology instructor Ruth Ley, a study co-author.

It was as if one group got far more calories from the same bowl of Cheerios than the other, Gordon said.

In a study of dozen dieting people, the results also were dramatic.

Before dieting, about 3 percent of the gut bacteria in the obese participants was Bacteroidetes. But after dieting, the now normal-sized people had much higher levels of Bacteroidetes — close to 15 percent, Gordon said.

"I think that gut bacteria affects body weight," said Virginia Commonwealth University pathology professor Richard Atkinson, who wasn't part of the research team and is president of Obetech Obesity Research Center in Richmond. "I don't think there's any doubt about that and they showed that."

The growing field of research puts more importance in the trillions of microbes that live in our guts and elsewhere, crediting it with everything from generations of people getting taller to increases in diabetes and asthma.

People are born germ-free, but within days they have a gut blooming with microbes. The microbes come from first foods — either breast milk or formula — the exterior environment, and the way the babies are born, said Stanford University medicine and microbiology professor David Relman, who was not part of the study.

For decades, doctors have treated bacteria in a "warlike" manner, yet recent research shows that "most encounters we have with microbes are very beneficial," Gordon said.

"Much of who we are and what we can do and can't do as human beings is directly related to microbial inhabitants," Relman said.

Guess what, dieting still works!

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You don't need a weatherman to know which way the wind blows - Robert A. Zimmerman

The lack of causation kills me.

Oh well, want to buy some Herbalife products?

B

Eat more than you burn - you get fat. Eat less than you burn, you'll lose weight. Eat healthy and often in small portions, you'll keep the weight off.

Why is this so confusing?

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- Brian


1989 500SEL Euro
1966 250SE Cabriolet
1958 BMW Isetta 600

The problem is that most people suffer from an overactive fork.

Food grows, it doesn't come from a factory. Don't eat industrial products. Eat food as close to the way it grew as possible. Hydrogenated fats, high fructose corn-syrup and flour have no place in your diet.

The bacteria in the gut is an overlooked aspect of health. Back to the cause and effect thing, bad diet affects the bacterial balance.

I was told that a B vitamin is a product of one of the gut bacteria. Taking vitamin B kills the bacteria that makes the vitamin B, around and around we go.

Interesting article Bot - but to me it's another example of media potentially or intentionally missing the mark on the research outcome, and/or trying to stoke the fires of an unsubstaniated theory simply for increased readership. The line above in the quote, to me, is the clincher.

I wonder if the obese person's diet and food choices are what help determine the gut bacterial population. In other words, a poor diet, lack of exercise, etc. could help produce conditions that would favor the selection of the type of bacteria referred to in the journal article. So yes, obese people have different bacteria in their guts, but perhaps this is already due to their being obese - in other words, a symptom and not a cause.

So it is just as likely that bacteria have a low to minimal effect on obesity but rather are simply enjoying the fruits thereof.

Just my cynical $0.02...

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Chris
2007 E550 4Matic - 61,000 Km - Iridium Silver, black leather, Sport package, Premium 2 package
2007 GL450 4Matic - 62,000 Km - Obsidian Black Metallic, black leather, all options
1998 E430 - sold
1989 300E - 333,000 Km - sold
1977 280E - sold
1971 250 - retired

"And a frign hat. They gave me a hat at the annual benefits meeting. I said. how does this benefit me. I dont have anything from the company.. So they gave me a hat." - TheDon