W-126 sunroof wind noise
 

With windows closed, I get a whooshing of air from sunroof once above 60-65 mph. It is almost a dull roar. Can I adjust for this in some way?

I've looked at my rubber seal around top. It looks fine, so I'm thinking it has to do with a firm close of the roof. Looks firms to the eye, but may not be.

Any way to adjust for this?

I had the same problem with my 300D. Here is the fix:
1) make sure that black plastic wind deflector is not riding on top of the chrome rail on either side
2) if the front edge of your sunroof is higher when closed then that will create the noise at high speed. I think the air deflected off the winshield creats air lift and opens it up wider. to fix that you'll need to losen first two philips screws on both rails and use a small slot screw driver tighten those two little screws thru a little hole until the sunroof is even with the roof.
3)if the back of the roof is lower than the roof in close position, you will have to take the sunroof liner off and adjust those screws and brackets on each side. Short cut for this is add washers in between the sunroof and those two holders in the middle.