I have done it in 4 hours.......however...
Hoses....motormounts....waterpump.....
It really depends on what you want
A water pump replacement pays 3.2 hours on some cars...this can add up!
It depends on a lot of factors.....

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2003 SLK 230 (85000)
1999 E300 Turbo Diesel (388,000)
1991 350SD Turbo Diesel (185,000)