Running your engine "on the bottle" is pretty safe, as long as you follow the kits instructions on installation and you don't go crazy with the jetting adjustments.

Nitrious has been around a long time at the drag strips, if you have any questions most any Rod Shop will usually have some pretty knowledgeable people working there.

Only upgrade you may need to perform along with the Nitrious kit install is a fuel pump rating increase, but only if you are going for large hp increases ususally.

Another downside, it's easy to run threw a bottle while having fun! You may need to buy at least 2 bottles when you buy the kit, that way you always have one on hand when you have had your fun with the other.