Molybdenum disulfide grease is well suited for low speed, high load, low tolerance applications where sliding or fretting is involved. The moly additive is a solid which can act as an abrasive in tight tolerance applications. It can also interfere with the circulation of grease in roller bearings. This results in the rollers going dry and sliding instead of rolling.

Some lubricant manufacturers (ie: Castrol and McLube) specifically recommend against the use of their moly grease in wheel bearings.