Are you more of a "scenery" guy or a "things man built" guy?

If you like scenery, the drive up the coast of CA on Highway 1 is more than an all-day affair, but worth it, and that time of year it should be pretty clear (though you never know). Of course if you're starting from northern AZ, you'd have to backtrack a little south to jump on it out near Thousand Oaks, but as I say it's worth it if you like the scenery. Stay in the TO area, then get up early and hit the road. Stay on 1 until after it joins 101 and stay on 101 up through Buellton and Solvang (great wineries in this area too, watch the movie Sideways!) and bypass Lompoc and Vandenberg, cutting back to Highway 1 at/after San Luis Obispo. Stay the night on the coast up towards Carmel, then do the 17 mile drive around the Pebble Beach area before continuing up 1 towards SF. Have the Lobster Roll Sandwich at Sam's Chowderhouse north of Half Moon Bay, then continue up to the City. PM me when you're going to be close and I'll come meet you at Sam's, that's one of the best sandwiches I've ever had (and I'm not a Lobster fan).

And I couldn't tell how much of the Grand Canyon you saw...but it's worth a detour if you haven't visited. The slot canyons in Bryce and Zion (southern Utah) are amazing as well.

A week is hardly enough time to do much of anything other than drive, though.