bolomiester, I always use a light coat of anti-seize on the threads only and use a torque wrench to tighten lug bolts to the specified torque value for that diameter lug bolt. Have never experienced lug bolts (with anti-seize on the threads) backing out. Do not use anti-seize on the seating area of the lug bolts or the wheels. Best to clean rusty threads with a wire brush before applying the anti-seize.

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Fred Hoelzle