Route? Planning to visit forum members along the way?

Safe travels! Be at ease, highway miles are the easiest. Tires, brakes, wheel bearings, cooling system: those are the most common trouble points, and if they hold up to daily driving duty, with the exception of wheel bearings, they will likely do just fine on the trip.

If you can check yourself or have a shop check the wheel bearings, that would be good. Alternatively just check them after your first hour on the road, if any wheel is noticeably warmer than the rest, you've got an issue to sort out (could be dragging brake or wheel bearing or low tire pressure).

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Respectfully,
/s/
M. Dillon
'87 124.193 (300TD) "White Whale", ~392k miles, 3.5l IP fitted
'95 124.131 (E300) "Sapphire", 380k miles
'73 Balboa 20 "Sanctification"
Charleston SC