Definitely worth sorting out, the fuel economy tells the tale. My SDL went up 4mpg by tweaking the IP, fixing the turbo, and advancing the timing. I used to run ~20/26, I've been routinely hitting 24/30 post-tweak. Not only did fuel consumption go down, but power went up noticeably.

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Current stable:
1995 E320 157K (Nancy)
1983 500SL 125K (SLoL)

Gone but not forgotten:
1986 300SDL (RIP)
1991 350SD
1991 560SEL
1990 560SEL
1986 500SEL Euro (Rusted to nothing at 47K!)

Gone and wanting to forget:
1985 524TD 167K (TotalDumpster™) [Definitely NOT a Benz]