Sounds like vacuum issues. Vacuum is required to close the defrost vent and to open the center vent. Check to make sure the vacuum line coming into the cabin isn't unplugged in the engine compartment.

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Current stable:
1995 E320 149K (Nancy)
1983 500SL 120K (SLoL)

Black Sheep:
1985 524TD 167K (TotalDumpster™)

Gone but not forgotten:
1986 300SDL (RIP)
1991 350SD
1991 560SEL
1990 560SEL
1986 500SEL Euro (Rusted to nothing at 47K!)