Hi,
I am not comfortable buying through the net since I get impatient waiting for the item. Just go to a real store.
You are buying a W140 blower regulator. All blower regulators regardless of what S-class series are the same.
Better try to remove your existing blower regulator on your E-class and bring it to a Benz parts store. If you are lucky, they may have one in stock. But if they don't, just get the S-class version and compare the wiring difference. It is a BEHR brand.