Maybe, at least on a 722.6. .

I've taken apart 2 722.6 trans that had high miles. ( 120 K range )

The 98 S320 trans was bought as a core with a broken center planet. ( thrust washer cage came apart and rollers broke gears.) The pan had metal bits but no fine shavings. Worn clutch material build up in the pan was nearly non existent. Filter was same date as trans build so I'd say the fluid was never changed. Clutches and steels were in excellent condition.

97 C230 bought as a working trans, filter was ~ 4 years newer than trans build. This one didn't have any metal bits and worn clutch material build up in the pan was nearly non existent. I haven't pulled the internals apart yet.

In both cases the fluid was brownish but translucent, still retaining a red color with no sign of being overheated / burnt.

In the past I've found some reference on the net that the fluid used in the 722.6 is designed to keep friction material in suspension so as the friction plates wear, the friction coefficient of the fluid rises to compensate. The down side I see is possible increased wear of sliding metal surfaces.

The 722.6 controller has a fluid life calculator and some other info as well that can be viewed using a MB scan tool. This makes me wonder if fluid life was used in shift calculations.