My wife's Sienna has 163,000 miles on it and it has been super. Replaced one ignition coil at about 155,000 and the rear latch handle broke at about the same time. Both were replaced for a total of $150 and a half hour's work on my part.
I can't pry my wife out of this vehicle. She loves it. Runs smooth as silk and still gets 26mpg on the highway too!
I sold my LX-450 to a buddy at 166,000 and it truly felt like it had 30,000 miles. Tight, quiet, like butter.
Never any breakdowns.
Those are the only two personal data points I have with Toyota, but they are both really good. They are also both from vehicles built 8-10 years ago. I guess we may have to watch and see what the '06 Toyotas are doing in 2016.