Freaking yea! I'm friends with a girl that loves to watch Desperate Housewives, on ABC at the same time as Family Guy. That was one hell of an argument the first Sunday night she came over. Needless to say she's at her house right now with her show and I"m watching Family Guy.
American Dad is pretty good too. I love the lines on the newspaper in the opening theme. My favorite was "Israel pulls out of Gaza. Gaza not pregnant."