I've had a 2001 2WD E320 wagon for the last several years. It averages 20-21MPG in suburban stop-and-go driving. Hwy is 27MPG, plus or minus 1. I should note that I drive it for maximum economy - modest acceleration, no leadfoot maneuvers, etc. The Munroney sticker says 21/27 for this car, and that's pretty much what I get.

- JimY