Our 2000 4Matic is presently getting about 25 mpg from a 70/30 highway/city mix. The highway is all rush-hour and can involve a fair bit of stop and go. In the coldest weather that drops to about 22 mpg, same mix.

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Jonathan

2011 Mazda2
2000 E320 4Matic Wagon
1994 C280 (retired)