The only problem I have with putting cross-drilled rotors on a vehicle designed for off-road use is the potential for getting debris imbedded in the holes and scoring the pads and/or possibly the rotors.

Otherwise, for a street-only vehicle, they would look pretty cool...

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2009 ML350 (106K) - Family vehicle
2001 CLK430 Cabriolet (80K) - Wife's car
2005 BMW 645CI (138K) - My daily driver
2016 Mustang (32K) - Daughter's car