Everyone has one around here, and most people love them. Remember only unhappy owners take the time to complain.
W210's are simple to fix, parts are cheap, quality is fine, they drive well, etc. I'd have no issue buying one. Just buy a good one, go cheap and buy junk, well thats what you get. Get a 2000-02 E320 with full records, no accidents, low miles, one owner, and it will be just as good as any other car of similer vintage.