Ford big-blocks are stout and thirsty, although no more than any other big block. I had an 4x4 F350 crew cab w/460 that I used for towing and hauling anything and everything within and beyond its limits. I had it for 6 years and put about 100K on it.

The one thing to keep in mind is that with RV's they generally have low miles but often sit for extended periods of time. You really want to be sure to go through and check all of the wires and hoses to make sure they haven't started deteriorating from lack of use. Make sure the tires aren't cracked and checked from sun exposure, too.

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1980 300TD-China Blue/Blue MBTex-2nd Owner, 107K (Alt Blau) OBK #15
'06 Chevy Tahoe Z71 (for the wife & 4 kids, current mule) '03 Honda Odyssey (son #1's ride, reluctantly) '99 GMC Suburban (255K+ miles, semi-retired mule) 21' SeaRay Seville (summer escape pod)