IMHO I hate little pistols with big caliber's. My friend has a little Kal Tec .38 which is a junk gun, and its to small IMHO the .38 round overpowers it. Lots of kick. I have big hands I have to watch the slide to or it will bite. It also came in a .32 which IMHO would have been a better round for that little pistol.
For a semi auto I would go with something slightly bigger, like a Walther PPK in 9mm. Or something from Sig or H&K. Or a nice S&W wheel gun in .32, those are expensive but they are damn nice.
It doesn't matter what you shoot, as long as it hits it will do the job.
http://www.youtube.com/watch?v=-aroWUQuPtU&feature=channel
Here is my friends CC gun, it doesn't have a safety either, just a long pull. The reviewer likes it but I don't.