In my experience, my E320 would not run with one of the pumps bad. It quit 2 times on me and had to have it towed,,, one time for each pump.

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95 SL500 Smoke Silver, Parchment 64K
07 E350 4matic Station Wagon White 34K
02 E320 4Matic Silver/grey 80K
05 F150 Silver 44K