I just replaced mine on my 06 e350 and it was very easy. I did disconnect the cable to the sensotronic "brick" under the hood. It has a locking mechanism on it that when it is pull upward, it disengages the plug. For safe measure, I went ahead and locked the car and made sure noone was around the car when I was doing the job. It takes more time to jack up the car and pull off the tires that it does to change the pads.

Good Luck!

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2001 ML320
1987 560SL
1970 280SE
1965 230SL