I found this.
http://www.peachparts.com/shopforum/showthread.php?t=149974&highlight=c280+door
probably the pin came loose.
UPDATE, evidently the 1995 C280's tumbler and spindle are a single piece. According to the dealer's schematic. Unless the OEM had a pin attaching the two and the replacement parts are now offered only as one piece ($85).
I found the single phillips screw at the end of the door just under the handle plane. The access hole in the frame is smaller than the screw head. I'm a bit reluctant to force it with a smaller head phillips driver.
Does the handle also have mounting screws behind the door panel????
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Not sure about the 'pump' noise yet. It is periodic like lasting 1-3 minutes. Maybe once or a couple of repeated times during a 25 min trip.
It also is emitting a high frequency noise from the front dash area, like a high note from rubbing a wet finger around a crystal wine glass lip.
some leads in archives... possible vac leak...???
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1979 300D 220 K miles
1995 C280 109 K miles
1992 Cadillac Eldorado Touring Coupe 57K miles SOLD
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1979 240D 140Kmiles (bought for parents)

*SOLD.
SAN FRANCISCO/(*San Diego)
1989 300SE 148 K miles *SOLD