old toyotas only put out ONE code for misfire, which can be anywhere in any cylinder in any part, So start with replacing the ignition cables, then the distro cap.

Vacuum checks are also good, It might also be the brake servo gone bad, I have experienced that.. It was a tail chase.

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2012 BMW X5 (Beef + Granite suspension model)

1995 E300D - The original humming machine (consumed by Flood 2017)
2000 E320 - The evolution (consumed by flood 2017)