I had problems in the window in my 2001 ML 320. The first problem was that the window was "sticking." Whenever I rolled up the window, streaks of grease would appear on the window. I brought this to the dealer, the problem was that the panels were too tight?? Lame excuse. 3 days later, the window stopped working completely. This was fixed by replacing entire panel of switches.
2 months later, window began to struggle as you have said. The motors were drawing way too many amps thus slowing the motor. All the motors were changed, and now the window is fine..goes up and down nice and fast without that struggle sound you hear in those older honda accords