In that situation, if a 45 ACP with 230 grain rounds is all you have, you run what you brung. It is said from skull observations that you CAN kill a bear with a 22 LR
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Looking at the skull - the only path for a small power bullet to kill a black bear is to enter from the ear canal for the sinus cavity. You need to shoot up the nose - not at the nose - to make this work. Likewise, you need to stand just slightly behind the bears head to get the right angle to hit it through the ear canal.
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If a 22 LR is all you have, why not. Me, I'd get a bigger caliber that I can shoot if I had a choice. Just because you "CAN" doesn't mean it is a good idea. You CAN have sex with your siblings but it might not be a good idea.