Fuses blow because of excessive current draw. If it blows once, the problem should be found before replacing it. As you've found, the fuse will continue to blow. There's probably a chaffed wire somewhere that's touching something it shouldn't or rubbed through to the chassis and only pops the fuse when it touches.

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Current stable:
1995 E320 157K (Nancy)
1983 500SL 125K (SLoL)

Gone but not forgotten:
1986 300SDL (RIP)
1991 350SD
1991 560SEL
1990 560SEL
1986 500SEL Euro (Rusted to nothing at 47K!)

Gone and wanting to forget:
1985 524TD 167K (TotalDumpster™) [Definitely NOT a Benz]